The present invention provides a bioactive coating composition, method and devices
for bodily fluid-contacting surfaces. The coating comprises a complex of Formula
II: wherein R1 is an C1-18alkyl or C6-32aryl group,
each R2 is independently selected from the group consisting of C1-18alkyl
and C6-32aryl, R3 is N or O, n is a number from 1 to 10,
and x in a number from 1 to about 30, directly bound to a heparin-activity molecule
via covalent bonding, with one or more bioactive molecules bound to the heparin-activity
molecule. The bioactive molecule may be an adhesive molecule such as fibronectin,
a growth factor such as basic fibroblast growth factor, or any other bioactive
molecule that binds, by any mechanism, to a heparin-activity molecule
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