The present invention relates to systems and methods for measuring one or more
physical characteristics of material such as tissue using optical radiation. The
system can use light that is scattered by a tissue layer to determine, for example,
the size of nuclei in the tissue layer to aid in the characterization of the tissue.
These methods can include the use of fiber optic devices to deliver and collect
light from a tissue region of interest to diagnose, for example, whether the tissue
is normal or precancerous.