Self-supporting, shaped, three-dimensional cross-linked proteinaceous
biopolymeric materials that may be implanted in vivo, and methods of making such
materials are disclosed. The biopolymeric materials most preferably include reinforcing
media, such as biocompatible fibrous or particulate materials. In use, the preformed,
shaped biopolymeric materials may be applied to tissue in need of repair and then
sealed around its edges with a liquid bioadhesive. In such a manner, repaired tissue
which is capable of withstanding physiological pressures may be provided.
