GnRH receptor antagonists are disclosed which have utility in the treatment
of a variety of sex-hormone related conditions in both men and women. The compounds
of this invention have the structure:
##STR1##
wherein A, R1, R2, R3a, R3b,
R4, R5, R6, and n are as defined herein, including
stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed
are compositions containing a compound of this invention in combination with a
pharmaceutically acceptable carrier, as well as methods relating to the use thereof
for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
