An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating
bone, cartilage, muscle, and nerve tissue formation. Frzb binds to and modulates
the activity of Wnt growth factors which play a role in various developmental and
neoplastic processes. The cDNA and protein sequences of human, bovine and Xenopus
Frzb are provided. Production and purification of recombinant Frzb are also described.
