Carboxypolysaccharides (CPS) including carboxymethyl cellulose
and their derivatives are provided that can be made into sponges, gels, membranes,
particulates and other forms, for a variety of antiadhesion, antithrombogenic,
drug delivery and/or hemostatic applications during surgery and pharmacological
therapeutics. CPSs derivatized with primary amines can be used alone or in combination
with poly(ethylene glycol) and poly(ethylene oxides) and other poly(alkylene oxides)
to form materials having improved drug delivery, antiadhesion, and hemostatic uses.
Applications include other types of chemical modifications of CPS to provide hydrogen,
ionic, Van der Walls interactions and/or covalent bonding with drugs, biologicals
and other therapeutic or diagnostic purposes.
