The invention provides isolated nucleic acids molecules, designated
muscarinic acetylcholine receptor 6 ("mACHR-6") nucleic acid molecules,
which encode polypeptides involved in the modulation of acetylcholine
responses in acetylcholine responsive cells. The invention also provides
antisense nucleic acid molecules, expression vectors containing mACHR-6
nucleic acid molecules, host cells into which the expression vectors have
been introduced, and non-human transgenic animals in which an mACHR-6
gene has been introduced or disrupted. The invention still further
provides isolated mACHR-6 polypeptides, fusion polypeptides, antigenic
peptides, and anti-mACHR-6 antibodies. Diagnostic, screening, and
therapeutic methods utilizing compositions of the invention are also
provided.
