The present invention features an isolated, intact virus associated with human
lymphoma, and originally isolated from a mantle cell lymphoma, referred to herein
as a mantle histiocyte retrovirus (MHRV). The invention also features compositions
and methods for detecting MHRV, as well as methods and compositions for propagating
MHRV in vitro, screening for anti-MHRV agents, and generation of attenuated MHRV strains.
