Disclosed are peptide and DNA compositions surprisingly found to be effective
in generating immune responses against the pathogenic fungi Coccidioides spp.,
the causative agents of coccidioidomycosis and Valley Fever. The invention thus
provides peptides and DNA constructs, combinations and related biological compositions,
and prophylactic and therapeutic methods of using such components to generate effective
immune responses against Coccidioides spp., including C. immitis.