A polypeptide is identified as being functionally included in a signal
transduction pathway having a biological effect. Contemplated
polypeptides are different from a retinoic acid receptor, a retinoid X
receptor, or a cellular retinoic acid binding protein, however bind a
retinoid or retinoid metabolite, and binding of the retinoid or retinoid
metabolite lead to a modulation of the biological effect. In particularly
contemplated methods, a retinoid or retinoid metabolite is administered
to a cell or mammal in a concentration effective to modulate the
biological effect.
