Heterologous lipidated proteins formed recombinantly are disclosed and
claimed. The expression system can be E. coli. The heterologous lipidated
protein has a leader sequence which does not naturally occur with the
protein portion of the lipidated protein. The lipidated protein can have
the Borrelia OspA leader sequence. The protein portion can be OspC, PspA,
UreA, Ure B, or a fragment thereof. Methods and compositions for forming
and employing the proteins are also disclosed and claimed.
