The present invention relates to a novel soluble IL-1 receptor accessory
molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In
particular, isolated nucleic acid molecules are provided encoding the
human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are
vectors, host cells and recombinant methods for producing the same.
Screening methods are futher provided for identifying agonist and
antagonists of IL-1 signal transduction. The invention further relates to
methods for treating physiologic and pathologic disease conditions with
IL-1R AcM antagonists.
