Compositions, methods, and devices are provided for inducing or enhancing
the growth, proliferation, regeneration of inner ear tissue, particularly inner
ear hair cells. In addition, provided are compositions and methods for prophylactic
or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition,
particularly for hearing impairments involving hair cell damage, loss, or degeneration,
by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their
agonists, alone or in combination.
