Protein suspensions comprising soluble and insoluble components are purified
via flocculation with anionic polymers, such as polyacrylamides, potato starch,
or modified cellulose. The procedure improves the efficiency of solid/liquid separations
and can minimize or eliminate the requirement for centrifugation and/or filtration
in large scale biotechnological processes. The method is particularly well suited
for the purification and clarification of protein suspensions containing soluble
somatotropin monomer using polyacrylamide and polysaccharide flocculants.
