Aptamers and antiaptamers
   
   

The present invention relates to: An aptamer comprising a circular oligonucleotide defining one to four target binding regions; An aptamer comprising an oligonucleotide defining two, three or four thrombin binding quadruplex regions separated by at least partially duplex regions, wherein the quadruplex regions comprise a GGTMGGXGGTTGG sequence wherein M represents A or T and X represents a sequence of two to five nucleotides and/or nucleotide analogues; An aptamer represented by formula (I): 5'D.sub.1, wQxD.sub.1D.sub.2yQzD.sub.2,3'--the variables are as defined in the specification; and Aptamers selected from specific sequences.

 
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