The present invention provides, inter alia, triphenylethylene derivatives, such
as, 3-{4-[6-(3-Methoxy-phenyl)-8,9-dihydro-7H-benzocyclohepten-5-yl]-phenyl}-acrylic
acid, as selective estrogen receptor modulators. Also provided are methods for
the treatment and/or prevention of estrogen stimulated diseases in mammals including
breast, uterine, ovarian, prostrate and colon cancer, osteoporosis, cardiovascular
disease, and benign proliferative disorders, as well as pharmaceutical compositions
of the compounds of the present invention.
