The present invention relates generally to the field of ligands for
nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the
treatment of disease conditions associated with defective or
malfunctioning nicotinic acetylcholine receptors, especially of the
brain. Further, this invention relates to novel compounds for example,
indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles,
which act as ligands for the .alpha.7 nAChR subtype, methods of preparing
such compounds, compositions containing such compounds, and methods of
use thereof.
