An implantable lead system includes an elongated device slideably engaged within a lumen of a lead body. A distal portion of the elongated device is slidable through a helix tip coupled to a distal end of the lead body by passing through a pierceable fluid-tight seal disposed in proximity to the distal end of the lead body; the seal prevents ingress of bodily fluid into the lumen of the lead body.

 
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> Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
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