The invention provides pyrrole-containing compounds and methods of use thereof. Kits and pharmaceutical compositions comprising the pyrrole compounds of the invention are also provided. The compounds and compositions disclosed herein are preferably used in the treatment of neurodegenerative diseases, cardiovascular diseases, proliferative diseases, neuroinflammatory disorders, vascular disorders with an inflammatory component, and visual disorders. In particular, methods and compositions for the treatment of stroke are disclosed herein.