Antibodies to intracellular domains of two or more kinds of protein tyrosine
phosphatases, methods for generation thereof and cells producing these antibodies
are disclosed. The antibody of the present invention may have specificity to intracellular
domains of phosphatase subunits of both of LAR and CD45, and may be useful for
analysis and quantitative determination of PTPs, identification and detection of
novel PTPs, and for obtaining novel phosphatases by cloning and the like, as well
as for developing useful diagnostic methods of insulin resistance and NIDDM, for
prophylaxis and diagnosis of various disease states of syndrome X that is based
on insulin resistance, and for prophylaxis and diagnosis of onsets of arteriosclerosis
and cardiac diseases.