The present invention is directed to the process for the preparation of
2'-deoxy-2'-halo-.beta.-L-arabinofuranosyl nucleosides, and in
particular, 2'-deoxy-2'-fluoro-.beta.-L-arabinofuranosyl thymine
(L-FMAU), from L-arabinose, which is commercially available and less
expensive than L-ribose or L-xylose, in ten steps. All of the reagents
and starting materials are inexpensive and no special equipment is
required to carry out the reactions.