The present invention is directed to compounds of formula (I), 1
which antagonize of the effects of melanin-concentrating hormone (MCH)
through the melanin concentrating hormone receptor which is useful for
the prevention or treatment of eating disorders, weight gain, obesity,
abnormalities in reproduction and sexual behavior, thyroid hormone
secretion, diuresis and water/electrolyte homeostasis, sensory
processing, memory, sleeping, arousal, anxiety, depression, seizures,
neurodegeneration and psychiatric disorders.