Novel CARD-14 polypeptides, proteins, and nucleic acid molecules are disclosed.
In addition to isolated CARD-14 proteins, the invention further provides CARD-14
fusion proteins, antigenic peptides and anti-CARD-14 antibodies. The invention
also provides CARD-14 nucleic acid molecules, recombinant expression vectors containing
a nucleic acid molecule of the invention, host cells into which the expression
vectors have been introduced and non-human transgenic animals in which a CARD-14
gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods
utilizing compositions of the invention are also provided.