A novel application of independent component analysis (ICA) to data acquired
by
a single sensor. The technique exploits the unique relationship between multiple
physiologic (source) and electronic (artifact) components in surface recorded sensory
nerve action potential (SNAP) waveforms that are evoked by different activating
magnitudes. A forward model of the SNAP is developed and used to test the approach
on a simplified data simulation. The method is applied to experimental data and
shown to be effective at separating artifact and source components and reconstructing
artifact-free traces. A method of automated reconstruction for use within an expert
system is also disclosed.