Apparatus and method for preparing microparticles using in-line solvent
extraction. An emulsion is formed by combining two phases in a static mixer. The
emulsion is combined with an extraction liquid in a blending static mixer. The
outflow of the blending static mixer is combined with additional extraction liquid.
The additional extraction liquid and the outflow of the blending static mixer can
be combined in a vessel, or through the use of a static mixer manifold that includes
a plurality of static mixers.