Implantable devices for use in a non-sterile environment of a patient's anatomy are medicated or include medication. For example, the housing of the device and/or members for securing the device to the patient's anatomy (e.g., the muscular esophageal wall) may be medicated to, among other things, prevent a rejection mechanism from being triggered, to prevent or reduce bacterial infection, or to promote tissue ingrowth. The medication may be for medicating tissue at the implant site, or for medicating some other portion of the patient's anatomy.