A removable data storage drive with improved protection from ambient contamination is provided. A first foam strip covered with a strip of plastic, at the bottom of the opening in the front panel of the disk drive, seals the opening against contamination while the disk(s) are spinning and during insertion and removal of the medium. A second foam strip, attached to the door of the disk drive, provides padding to the door and further seals the opening against contamination. A first plastic seal made out of plastic is attached to the removable disk drive covering the entire bottom portion of the drive. This seal (1) prevents extrinsic contamination from entering the removable disk drive through the gaps and openings on the bottom of the drive by acting as a barrier to blockade any airborne particles from being pulled into the negative pressurized areas of the drive, and (2) prevents shorting of any electrical components mounted on the bottom of the drive. A second plastic seal is positioned over the cartridge eject and head locking mechanism of the disk drive in order to prevent debris from entering the disk drive from this mechanism.