Histidine ammonia lyase (HAL) isolated from Corynebacteriaceae can decrease
serum histidine levels, induce accumulation of urocanic acid, and is not inhibited
by L-histidinol. As a result, histidine ammonia lyases similar to the one isolated
from Corynebacteriaceae are uniquely suitable for combination therapy with L-histidinol
to treat histidine- and/or histamine-dependent pathologies, for example, infectious
viruses, such as human Respiratory Syncytial Virus (RSV), Herpes Simplex Virus
(HSV), and Human Immunodeficiency Virus (HIV), as well as cancers.