GnRH receptor antagonists are disclosed which have utility in the treatment
of a variety of sex-hormone related conditions in both men and women. The compounds
of this invention have the structure:
##STR1##
wherein A, R1, R2, R3a, R3b,
R4, R5, R6, R7 and n are as defined
herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts
thereof. Also disclosed are compositions containing a compound of this invention
in combination with a pharmaceutically acceptable carrier, as well as methods relating
to the use thereof for antagonizing gonadotropin-releasing hormone in a subject
in need thereof.
