The invention pertains to murine TLR9 and related TLR9s which include murine-specific
amino acids, as well as nucleic acids which encode those polypeptides. The present
invention also includes fragments and biologically functional variants of the murine
TLR9. The invention further relates to methods of using such murine and non-murine
TLR9 nucleic acids and polypeptides, especially in methods for screening for agonists
and antagonists of immunostimulatory CpG nucleic acids. Also included are murine
TLR9 inhibitors which inhibit murine TLR9 activity by inhibiting the expression
or function of murine TLR9. In a further aspect the present invention pertains
to murine TLR7 and murine TLR8, as well as related TLR7 and TLR8 molecules which
include murine-specific amino acids, as well as nucleic acids which encode those
polypeptides. The present invention also includes fragments and biologically functional
variants of the murine TLR7 and TLR8. Methods are included for screening for ligands
of TLR7 and TLR8, as well as for inhibitors and agonists and antagonists of signaling
mediated by TLR7 and TLR8.