Compounds which mimic the secondary structure of helical regions of biologically
active peptides and proteins having the following structure:
##STR1##
including pharmaceutically acceptable salts and stereoisomers thereof,
wherein Y, A, B, R1 and R2 are as defined herein. Such compounds
have utility over a wide range of applications, including use as diagnostic and
therapeutic agents. In particular, compounds of this invention, and pharmaceutical
compositions containing the same, are neurokinin (tachykinin) antagonists. Libaries
contaning the compounds of this invention are also disclosed, as well as methods
for screening such libaries identify biologically active members.
