The invention concerns a biologically active material essentially comprising at least an insolubilized dextran derivative of general formula DMC_aB_bSU_cS_d and at least a growth factor having an activity on osteoarticular, dental and/or maxillofacial tissues, and the method for preparing same. The invention also concerns the uses of said biomaterial for preparing a repair or filing material, such as an implant, for osteoarticular, dental or maxillofacial applications and for preparing an orthopaedic, dental or maxillofacial prosthesis, and the prosthesis coated with said biologically active material.