Conformationally constrained compounds that mimic the secondary
structure of reverse-turn regions of biologically active peptides and proteins
having the following structure are disclosed:
##STR1##
wherein A, R1, R2, R2a and R3 are
as defined herein. Such compounds have utility over a wide range of fields, including
use as diagnostic and therapeutic agents. In particular, compounds of this invention
are useful in pharmaceutical compositions as anti-inflammatory agents as well as
inhibitors of central nervous disorders. Libraries containing the compounds of
this invention are also disclosed, as well as methods for screening the same to
identify biologically active members.
