A process for preparing regioselectively an optically active 1-halogeno-2-hydroxypropyl
compound of the following formula;
##STR1##
- wherein X is halogen atom and Nu is a heteroatom having a substituent,
and an optically active glycidyl compound of the formula;
##STR2##
which comprises reacting an optically active epihalohydrin of the formula;
##STR3##
with a neucleophilic agent,
in the presence of a metal complex of the formula;
##STR4##
- wherein n is an integer of 0, 1 or 2, Y1, Y2 and
Y3 are hydrogen atom, etc., and Y2 and Y3 may
form a ring such as benzene, A is a counterion and M is a metal ion, and further
subjecting the compound (4) to reaction with a base to prepare the optically active
glycidyl compound (5).
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