This invention provides a compound of the formula:
##STR1##
or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated
or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated
five membered carbocyclic, wherein the 4-(sulfonyl)phenyl and the 4-substituted
phenyl in the formula (I) are attached to ring atoms of Ring A, which are adjacent
to each other; R1 is optionally substituted aryl or heteroaryl, with
the proviso that when A is pyrazole, R1 is heteroaryl; R2 is
C1-4 alkyl; halo-substituted C1-4 alkyl, C1-4 alkylamino,
C1-4 dialkylamino or amino; R3, R4 and R5
are independently hydrogen, halo, C1-4 alkyl, halo-substituted
C1-4 alkyl or the like; or two of R3, R4 and R5
are taken together with atoms to which they are attached and form a 4-7 membered
ring. R6 and R7 are independently hydrogen, halo, C1-4
alkyl, halo-substituted C1-4 alkyl, C1-4 alkoxy, C1-4
alkylthio, C1-4 alkylamino or N,N-di C1-4 alkylamino;
and m and n are independently 1, 2, 3 or 4.
This invention also provides a pharmaceutical composition useful for the treatment
of a medical condition in which prostaglandins are implicated as pathogens.