The present invention includes novel methods and compositions for inhibiting or reducing steroid-dependent gene activation including the administration of at least two compounds that act different steps within a steroid receptor gene activation pathway. Preferred methods may include administering a first compound able to induce degradation of a steroid receptor and administering a second compound able to inhibit gene activation at a different step of the steroid receptor pathway. Steroid-dependent gene activation may be reduced or inhibited, modulated or controlled greater when the at least two of the compounds are administered in combination or together.