A method and apparatus for controlling a ventricular assist device are disclosed. The method includes the step of providing a ventricular assist device which can be defined in terms of operational parameters such as pump speed or current. Measuring at least one physiological parameter reflecting a physiological state corresponding to a patient. Correlating at least one physiological parameter measured from the patient to at least one operational parameter using an estimation method. Selecting a physiological state definable by desired values of the physiological parameters. Monitoring at least one operational parameter. Controlling input values of the operational parameter based on output from the monitoring step. The apparatus includes a pump driven by a motive drive and having an impeller. A sensor detects the value of an operational parameter of the pump. A processor provides a statistical correlation between patients physiological parameter and the operational parameter of the pump and adjusts the operational parameter to affect a predetermined optimal physiological state.