The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and recruitment for the treatment and prevention of vascular disorders in mammals.

 
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> Modulation of tyrosinase expression

> Methods for preparing 7-(2'-substituted-beta-D-ribofuranosyl)-4-(NR2R3)-5-- (substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
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