A compound of the formula (I):
##STR1##
- wherein R1 is hydroxy and the like; R2 is optionally
substituted lower alkyl and the like; R3 is hydrogen atom and the like;
R4 is optionally substituted arylene and the like;
- R5 is a group represented by the formula:
##STR2##
- and the like; R6 is optionally substituted aryl and the like,
- its optically active substance, its prodrug, their pharmaceutically
acceptable salt, or solvate thereof and metalloproteinase inhibitors containing them.
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