An interactive drug delivery system includes a drug delivery module, an optical
probe, a local controller, and an optional central controller. The drug delivery
module is constructed and arranged to deliver selected amounts of a drug into a
subject. The optical probe is constructed and arranged to detect in a selected
tissue region of the subject a manifestation caused by the delivered drug. The
local controller is constructed and arranged to receive data from or transmit data
to the optical probe and the drug delivery module. The local controller is arranged
to correlate optical data, received from the optical probe, to selected data and
provide signals to the drug delivery module for adjusting the amounts of the drug
to be delivered into the subject.