The invention is a method and supplement for treatment of symptoms of Alzheimer's disease, dementia, depression, and combination thereof, comprising: from about 20 wt % to about 70 wt % emu oil, wherein the emu oil further comprises from about 1 wt % to about 12 wt % linolenic acid; from about 5 wt % to about 30 wt % l-arginine; from about 5 wt % to about 30 wt % pyroglutamate; from about 0.5. wt % to about 20 wt % B-12 methylcobalamin; and from about 0.5 wt % to about 20 wt % calcium, wherein the supplement is adapted for crossing a blood brain barrier, and for fortification of phospholipids in neurotransmitters of a brain to increase cell proliferation for treatment of symptoms of Alzheimer's disease, dementia, depression, and combinations thereof.