Application-specific midsoles and method of designing midsoles are described herein. The midsole includes a plurality of cells that extend generally upward from a generally flat support structure and provide the ability to selectively attenuate the ground reaction forces that result when one engages in activities associated with the application for which the shoe midsole is designed. The midsole comprises a plurality of zones. The shock attenuation properties of each zone is determined by the geometry of the cells in the zone and material composition of the midsole.