The present invention relates to compositions comprising folic acid, vitamin B6 and vitamin B12, and to the use thereof in hyperhomocysteinemia for regulating homocysteine levels. The compositions can thus be used in particular for the preventive and acute treatment of vascular disorders, pregnant women and neurodegenerative disorders. Descriptions are given in particular of pharmaceutical compositions and food supplements with a corresponding active ingredient combination, and compositions in the form of commercial packs with corresponding combination products or single-ingredient products for combined use.