GnRH receptor antagonists are disclosed which have utility in the treatment
of a variety of sex-hormone related conditions in both men and women. The compounds
of this invention have the structure:
##STR1##
wherein R1, R2, R3a, R3b, R4,
R5, and n are as defined herein, including stereoisomers, prodrugs and
pharmaceutically acceptable salts thereof. Also disclosed are compositions containing
a compound of this invention in combination with a pharmaceutically acceptable
carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing
hormone in a subject in need thereof.
