A system, related apparatus, method and a computer accessible storage medium for operation environment migration are provided. The system includes a first PC, a second PC, and a USB migration cable having a first USB connector and a second USB connector. The USB migration cable includes a first USB connector, a second USB connector, a first USB controller coupled to the first USB connector, having an embedded first flash memory storing a non-volatile first firmware for operating the first USB controller, and a second USB controller coupled to the first USB controller, having an embedded second flash memory storing a non-volatile second firmware for operating the second USB controller, where the USB migration device uses the first USB controller to couple a first PC and the second USB controller to couple a second PC so that the second PC can automatically execute the drivers and the applications installed in the first PC to operate the USB migration device according to the autorun image file. The first PC can obtain the operation environment of the second PC through the USB migration device. Preferably, the operation environment includes the application installed, address book of the e-mail program, and the favorite list of the internet browser.