A process is provided for preparing a dipeptidyl peptidase IV inhibitor of the structure 1 wherein 2 is treated with TFAA in isopropyl acetate to protect the tertiary hydroxyl group as a trifluoroacetate group to form 4 3 (which is a novel intermediate) which is converted to acid chloride compound 5 4 (which is a novel compound) using Vilsmeier reagent or other chloro reagent and coupled with compound 6 in a heterogeneous mixture of ethyl acetate and aqueous bicarbonate to give compound 7 5 The N,O-bis(trifluoroacetyl) groups of compound 7 are deprotected to give free base compound 10.

 
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> (2S)-2-amino-a-{[2-(ethanimidoylamino) ethyl]thio}butanoic acid, a nitric oxide synthase inhibitor, in stabilized pharmaceutical dosage forms

~ 00213