The present invention relates to methods and compositions for the diagnosis and
treatment of hematological disorders, including, but not limited to, apalstic anemia,
hemophilia, sickle cell anemia, thalassisemia, blood loss and other blood disorders,
e.g., blood diorders related to bone marrow irradiation or chemotherapy treatment
or renal failure. The invention further provides methods for identifying a compound
capable of treating a hematological disorder. The invention also provides methods
for identifying a compound capable of modulating a hematopoietic cell activity.
Yet further, the invention provides a method for modulating a hematopoietic cell
activity. In addition, the invention provides a method for treating a subject having
a hematological disorder characterized by aberrant 2777 polypeptide activity or
aberrant 2777 nucleic acid expression. In another aspect, the invention provides
methods for increasing hematopoietic cell proliferation in a subject and methods
for modulating hematopoietic cell apoptosis in a subject.