The present invention relates to compounds comprising the following formula:
These compounds are useful as pharmacologically active compounds. They exhibit
an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis
of cardiovascular disorders such as thromboembolic diseases or restenoses. These
compounds are reversible inhibitors of the blood clotting enzymes factor Xa (FXa)
and/or factor VIIa (FVIIa), and can generally be used to treat, prevent, or cure
conditions in which an undesired activity of factor Xa and/or factor VIIa is present,
or where inhibition of factor Xa and/or factor VIIa is intended. The invention
further relates to processes for the preparation of these compounds, methods of
their use (e.g., as active ingredients in pharmaceuticals), and pharmaceutical
preparations comprising them.