2-pyrrolidinone derivatives which have in position 4 at least one substituent are described herein. Methods of treating polyglutamine disorders such as Huntington's disease, dentorubropallidoluysian atrophy (DRPLA), spinal and bulbar muscular atrophy (SBMA), and spinocerebellar ataxias with 2-pyrrolidinone derivatives are also descibed.

 
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