An anti-theft device for a vehicle with tyre wheels includes an immobilization device, at least one detection control unit, and at least one sensor. The immobilization device activates an anti-theft procedure. The at least one detection control unit is connected to the immobilization device and verifies an alarm condition. The at least one sensor is associated with one or more of the tyre wheels, communicates with the at least one detection control unit, detects movement of one or more of the tyre wheels, and detects inflation pressure of one or more of the tyre wheels. A method for activating an anti-theft device for a vehicle with tyre wheels includes detecting an alarm condition from at least one of the tyre wheels, receiving the detected condition, and activating an anti-theft procedure.